Design, synthesis and fungicidal evaluation of novel psoralen derivatives containing sulfonohydrazide or acylthiourea moiety.

ABSTRACT: To search a novel lead structure for antiphytopathogenic fungus agent, a series of novel psoralen derivatives possessing sulfonohydrazide or acylthiourea structure were designed and synthesized, and their fungicidal activity against seven phytopathogens was evaluated. Their structures were confirmed by melting points, ¹H NMR, ¹³C NMR and HRMS, and the typical crystal structure was determined by X-ray diffraction for validation. Preliminary fungicidal activity showed that some of the title compounds exhibited certain-to-high fungicidal activity. Compound I-13 exhibited good fungicidal activity against Botrytis cinerea, Cercospora arachidicola and Physalospora piricola with EC₅₀ values of 12.49, 13.22 and 12.12 μg/mL, respectively. Compounds II-9 and II-15 sh

SUBMITTER: Dong J 

PROVIDER: S-EPMC9167667 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature