Cytomegalovirus and Toxoplasma Gondii Serostatus Prospectively Correlated With Problems in Self-Regulation but not Executive Function Among Older Adults.

ABSTRACT:

Objective

Cytomegalovirus (CMV) and Toxoplasma gondii are organisms that may infect the brain and have cognitive and behavioral consequences. We hypothesized that these latent infections would be prospectively associated with poorer cognition and more problems in self-regulation among older adults.

Methods

Older adults (n = 138, mean age = 75.5 years, 59% women) had CMV and T. gondii serostatus tested, crystallized intelligence estimated (North American Adult Reading Test), and executive function (EF; e.g., Trail Making Test) and self-regulation (Behavior Regulation Inventory of Executive Function-Adult) assessed in visits occurring every 6 months (mean visits = 16).

Results

CMV+ people (79%) had significantly poorer self-regulation versus CMV- people (21%; behavioral

SUBMITTER: Segerstrom SC 

PROVIDER: S-EPMC9167754 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature