Circulating complement factor H levels are associated with disease severity and relapse in autoimmune hepatitis.

ABSTRACT:

Background & aims

The complement system plays pivotal roles in innate immunity. Mannose-binding lectin-associated serine protease (MASP)-2 plays essential roles in the activation of the lectin complement pathway. Complement factor H acts as a critical negative regulator of the alternative complement pathway. The association of circulating MASP-2 and factor H with the clinical features of patients with autoimmune hepatitis (AIH) is unclear.

Methods

A total of 63 patients with AIH were recruited for this study. The serum levels of MASP-2, factor H, and C3a were measured, and their associations with the clinical features of AIH were analyzed.

Results

The circulating C3a levels were higher in patients with AIH than in the controls. The circulating MASP-2 and factor H leve

SUBMITTER: Hayashi M 

PROVIDER: S-EPMC9167978 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature