Structural dynamics reveal isolate-specific differences at neutralization epitopes on HIV Env.
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ABSTRACT:
SUBMITTER: Hodge EA
PROVIDER: S-EPMC9167985 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Publications
Structural dynamics reveal isolate-specific differences at neutralization epitopes on HIV Env.
Hodge Edgar A EA Naika Gajendra S GS Kephart Sally M SM Nguyen Adam A Zhu Richard R Benhaim Mark A MA Guo Wenjin W Moore John P JP Hu Shiu-Lok SL Sanders Rogier W RW Lee Kelly K KK
iScience 20220523 6
The envelope glycoprotein (Env) is the sole target for neutralizing antibodies against HIV and the most rapidly evolving, variable part of the virus. High-resolution structures of Env trimers captured in the pre-fusion, closed conformation have revealed a high degree of structural similarity across diverse isolates. Biophysical data, however, indicate that Env is highly dynamic, and the level of dynamics and conformational sampling is believed to vary dramatically between HIV isolates. Dynamic d ...[more]
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