Morphological and transcriptional evaluation of multiple facial cutaneous hyperpigmented spots.

ABSTRACT:

Background

Morphological characteristics of major facial hyperpigmented spots have been well documented. However, detailed alterations of respective transcriptional profile for each spot and in-depth comparisons across multiple spot types have not been reported.

Objectives

To comprehensively assess and compare multiple facial hyperpigmented spot types at the morphological and molecular levels by utilising transcriptional expression profiling with correlation to quantified histological features.

Methods

Multiple types of facial spot biopsies were collected from Chinese women and compared to additional biopsies taken from adjacent healthy skin. The types of spots included Solar Lentigos with both elongated dermal-epidermal junction (DEJ) (SL[E]) and flat DEJ (SL[F]), Se

SUBMITTER: Hakozaki T 

PROVIDER: S-EPMC9168023 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature