Dataset Information

A case of bilateral injection abscesses caused by Graphium type of Scedosporium apiospermum.

ABSTRACT: Fungal infections with non-Aspergillus species are increasingly reported even among immunocompetent individuals. We report a case of bilateral injection abscesses by Scedosporium apiospermum in an immunocompetent patient. This rare fungus was isolated and identified by culture from the surgical tissue and was confirmed by Vitek MS and sequencing of the internal transcribed spaces region of rDNA. The patient is being treated with Voriconazole for the past 3 months with no recurrence of the abscesses.

SUBMITTER: K S

PROVIDER: S-EPMC9168045 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

A case of bilateral injection abscesses caused by Graphium type of Scedosporium apiospermum.

K Sravanti S B Pravalika P M Pavani P M Ashwini A V Lakshmi L

Medical mycology case reports 20220514

Fungal infections with non-Aspergillus species are increasingly reported even among immunocompetent individuals. We report a case of bilateral injection abscesses by Scedosporium apiospermum in an immunocompetent patient. This rare fungus was isolated and identified by culture from the surgical tissue and was confirmed by Vitek MS and sequencing of the internal transcribed spaces region of rDNA. The patient is being treated with Voriconazole for the past 3 months with no recurrence of the absces ...[more]

PMID: 35676922

Similar Datasets

Project description:BackgroundUbiquitous fungi of the Scedosporium apiospermum species complex (SASC) cause various opportunistic infections. Posterior subtenon triamcinolone acetonide (STTA) injection is a standard therapy for intraocular inflammation and macular edema. We report a case of Scedosporium apiospermum infectious scleritis after a posterior STTA injection.Case presentationA 75-year-old man received a posterior STTA injection to treat macular edema in his left eye. After 3 months, he complained of ocular pain and hyperemia in his left eye. Examination showed a subtenon abscess in the site corresponding with the STTA injection. After incising the abscess, the smear revealed numerous conidia-like structures. Although we suspected fungal infection and started topical voriconazole (VRCZ) and levofloxacin, the inflammation of the eye worsened. Fungal culture revealed filamentous fungus growth. Subsequently, we added systemic VRCZ and performed surgical debridement of the infected sclera and Tenon's capsule. Pathology of the sclera showed fungal hyphae. The antifungal susceptibility test revealed low minimum inhibitory concentrations for micafungin, VRCZ and miconazole (0.06, 0.25 and 0.5 μg/mL, respectively). After 2 months, the ciliary injection subsided and VRCZ therapy was stopped. However, subtenon abscess recurred 1 month after discontinuation of topical VRCZ. Surgical debridement and topical VRCZ were resumed, with the eye finally improving after 5 months of management. The fungal species was identified as Scedosporium apiospermum sensu stricto morphologically and by DNA sequencing.ConclusionsThis case was successfully treated by topical and systemic VRCZ and repeated surgical debridement. Infectious scleritis caused by SASC rarely develops after posterior STTA. SASC can produce conidia in the enclosed subtenon space. Late-onset infectious scleritis after a posterior STTA injection suggests the presence of a fungal infection, including SASC, thereby requiring extensive and prolonged medical and surgical treatment.

Dataset Information

A case of bilateral injection abscesses caused by Graphium type of Scedosporium apiospermum.

Publications

A case of bilateral injection abscesses caused by Graphium type of Scedosporium apiospermum.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets