Development of Two Diagnostic Prediction Models for Leptomeningeal Metastasis in Patients With Solid Tumors.

ABSTRACT:

Objectives

For accurate diagnosis of leptomeningeal metastasis (LM) and to avoid unnecessary examinations or lumber puncture (LP), we develop two diagnostic prediction models for patients with solid tumors.

Study design setting and participants

This is a retrospective cohort study launched at the Second Affiliated Hospital of Dalian Medical University. In total, 206 patients who had been admitted between January 2005 and December 2021 with a solid tumor and clinical suspicion of LM were enrolled to develop model A. In total, 152 patients of them who underwent LPs for cytology and biochemistry were enrolled to develop model B.

Model development

Diagnostic factors included skull metastasis, active brain metastasis, progressed extracranial disease, number of extracranial

SUBMITTER: Gao T 

PROVIDER: S-EPMC9168081 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature