Memory B Cell Activation Induced by Pertussis Booster Vaccination in Four Age Groups of Three Countries.

ABSTRACT:

Background

Immunogenicity of acellular pertussis (aP) vaccines is conventionally assessed by measuring antibody responses but antibody concentrations wane quickly after vaccination. Memory B cells, however, are critical in sustaining long-term protection and therefore may be an important factor when assessing pertussis immunity after vaccination.

Aim

We studied pertussis specific memory B cell (re)activation induced by an aP booster vaccination in four different age groups within three countries.

Materials and methods

From a phase IV longitudinal interventional study, 268 participants across Finland, the Netherlands and the United Kingdom were included and received a 3-component pertussis booster vaccine: children (7-10y, n=53), adolescents (11-15y, n=66), young adult

SUBMITTER: Versteegen P 

PROVIDER: S-EPMC9168128 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature