Differential tractography as a dynamic imaging biomarker: A methodological pilot study for Huntington's disease.

ABSTRACT: Huntington's disease (HD) is a neurodegenerative disorder characterized by motor, psychiatric, and cognitive symptoms. Due to its diverse manifestations, the scientific community has long recognized the need for sensitive, objective, individualized, and dynamic disease assessment tools. We examined the feasibility of Differential Tractography as a biomarker to evaluate correlation of symptom severity and of HD progression at the individual level. Differential tractography is a novel tractography modality that maps pathways with axonal injury characterized by a decrease of anisotropic diffusion pattern. We recruited sixteen patients scanned at 0-, 6-, and 12-month intervals by diffusion MRI scans for differential tractography assessment and correlated its volumetric findings with the Unifie

SUBMITTER: Barrios-Martinez JV 

PROVIDER: S-EPMC9168197 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature