Tumor Microbiome in Nasopharyngeal Carcinoma and Its Association With Prognosis.

ABSTRACT:

Introduction

Previous studies have reported a close relationship between cancer and microbes, particularly gut and tumor microbiota; however, the presence of tumor microbiome in nasopharyngeal carcinoma (NPC) and its role in the prognosis of NPC remain unclear.

Methods

We collected 64 samples including tissues from 50 patients with NPC (NPC group) and 14 patients with chronic nasopharyngitis (control group) receiver operating characteristics and we applied 16S ribosome RNA gene sequencing of all samples to assess microbiome profiles and immunohistochemistry to detect tumor microbiome in NPC.

Results

Patients in the control group harbored higher species diversity than those in the NPC group; however, the beta diversity was more distinct in the NPC group. In total, thre

SUBMITTER: Zhong G 

PROVIDER: S-EPMC9168217 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature