The influence of white matter lesions on the electric field in transcranial electric stimulation.

ABSTRACT:

Background

Transcranial direct current stimulation (tDCS) is a promising tool to enhance therapeutic efforts, for instance, after a stroke. The achieved stimulation effects exhibit high inter-subject variability, primarily driven by perturbations of the induced electric field (EF). Differences are further elevated in the aging brain due to anatomical changes such as atrophy or lesions. Informing tDCS protocols by computer-based, individualized EF simulations is a suggested measure to mitigate this variability.

Objective

While brain anatomy in general and specifically atrophy as well as stroke lesions are deemed influential on the EF in simulation studies, the influence of the uncertainty in the change of the electrical properties of the white matter due to white matter lesio

SUBMITTER: Kalloch B 

PROVIDER: S-EPMC9168230 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature