Association of Anti-Rotavirus IgA Seroconversion with Growth, Environmental Enteric Dysfunction and Enteropathogens in Rural Pakistani Infants.

ABSTRACT:

Background

The underperformance of oral vaccines in children of low- and middle-income countries is partly attributable to underlying environmental enteric dysfunction (EED).

Methodology

We conducted a longitudinal, community-based study to evaluate the association of oral rotavirus vaccine (Rotarix®) seroconversion with growth anthropometrics, EED biomarkers and intestinal enteropathogens in Pakistani infants. Children were enrolled between three to six months of their age based on their nutritional status. We measured serum anti-rotavirus immunoglobulin A (IgA) at enrollment and nine months of age with EED biomarkers and intestinal enteropathogens.

Results

A total of 391 infants received two doses of rotavirus (RV) vaccine. 331/391 provided paired blood samples. Of

SUBMITTER: Ahmed S 

PROVIDER: S-EPMC9168439 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature