Auditory driven gamma synchrony is associated with cortical thickness in widespread cortical areas.

ABSTRACT:

Objective

Gamma synchrony is a fundamental functional property of the cerebral cortex, impaired in multiple neuropsychiatric conditions (i.e. schizophrenia, Alzheimer's disease, stroke etc.). Auditory stimulation in the gamma range allows to drive gamma synchrony of the entire cortical mantle and to estimate the efficiency of the mechanisms sustaining it. As gamma synchrony depends strongly on the interplay between parvalbumin-positive interneurons and pyramidal neurons, we hypothesize an association between cortical thickness and gamma synchrony. To test this hypothesis, we employed a combined magnetoencephalography (MEG) - Magnetic Resonance Imaging (MRI) study.

Methods

Cortical thickness was estimated from anatomical MRI scans. MEG measurements related to exposure of 40 H

SUBMITTER: Schuler AL 

PROVIDER: S-EPMC9168448 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature