Leaky gut model of the human intestinal mucosa for testing siRNA-based nanomedicine targeting JAK1.

ABSTRACT: Complex in vitro models of human immune cells and intestinal mucosa may have a translation-assisting role in the assessment of anti-inflammatory compounds. Chronic inflammation of the gastrointestinal tract is a hallmark of inflammatory bowel diseases (IBD). In both IBD entities, Crohn's disease and ulcerative colitis, impaired immune cell activation and dysfunctional epithelial barrier are the common pathophysiology. Current therapeutic approaches are targeting single immune modulator molecules to stop disease progression and reduce adverse effects. Such molecular targets can be difficult to assess in experimental animal models of colitis, due to the disease complexity and species differences. Previously, a co-culture model based on human epithelial cells and monocytes arranged in a physi

SUBMITTER: Hartwig O 

PROVIDER: S-EPMC9168449 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature