Risk of Bacterial, Viral, and Fungal Infections in Patients With Solid Malignant Tumors Treated With Curative Intent Radiation Therapy.

ABSTRACT:

Purpose

The incidence, etiology, and association of infections with radiation therapy (RT)-induced lymphopenia in patients with solid tumors is not well elucidated.

Methods and materials

We identified possible, probable, and definite infections caused by bacteria, fungi, and viruses, combining data on medication, microbiology, and diagnoses. Definite infections had either a diagnosis or a positive microbiological isolation. We analyzed the incidence and adjusted incidence-rate ratio of infections in the year after the start of RT among patients who received RT plus chemotherapy and RT monotherapy, by type of infection and according to the degree of RT-induced lymphopenia.

Results

A total of 4450 of 6334 (70.3%) patients experienced 11264 infections overall; 1424 (22.5

SUBMITTER: Terrones-Campos C 

PROVIDER: S-EPMC9168504 | biostudies-literature | 2022 Nov-Dec

REPOSITORIES: biostudies-literature