Protection of bacteriophage-sensitive Escherichia coli by lysogens.

ABSTRACT: SignificanceSome viruses that infect bacteria, temperate bacteriophages, can confer immunity to infection by the same virus. Here we report λ-immune bacteria could protect λ-sensitive bacteria from killing by phage λ in mixed culture. The protection depended on the extent to which the immune bacteria were able to adsorb the phage. Reconciling modeling with experiment led to identifying a decline in protection as bacteria stopped growing. Adsorption of λ was compromised by inhibition of bacterial energy metabolism, explaining the loss of protection as bacterial growth ceased.

SUBMITTER: Brown S 

PROVIDER: S-EPMC9168506 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature