Bacterial-type ferroxidase tunes iron-dependent phosphate sensing during Arabidopsis root development.

ABSTRACT: Access to inorganic phosphate (Pi), a principal intermediate of energy and nucleotide metabolism, profoundly affects cellular activities and plant performance. In most soils, antagonistic Pi-metal interactions restrict Pi bioavailability, which guides local root development to maximize Pi interception. Growing root tips scout the essential but immobile mineral nutrient; however, the mechanisms monitoring external Pi status are unknown. Here, we show that Arabidopsis LOW PHOSPHATE ROOT 1 (LPR1), one key determinant of Fe-dependent Pi sensing in root meristems, encodes a novel ferroxidase of high substrate specificity and affinity (apparent K_M ∼ 2 μM Fe²⁺). LPR1 typifies an ancient, Fe-oxidizing multicopper protein family that evolved early upon bacterial land colonizat

SUBMITTER: Naumann C 

PROVIDER: S-EPMC9168544 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature