Proteomic elucidation of the targets and primary functions of the picornavirus 2A protease.
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ABSTRACT: Picornaviruses are small RNA viruses that hijack host cell machinery to promote their replication. During infection, these viruses express two proteases, 2Apro and 3Cpro, which process viral proteins. They also subvert a number of host functions, including innate immune responses, host protein synthesis, and intracellular transport, by utilizing poorly understood mechanisms for rapidly and specifically targeting critical host proteins. Here, we used proteomic tools to characterize 2Apro interacting partners, functions, and targeting mechanisms. Our data indicate that, initially, 2Apro primarily targets just two cellular proteins: eukaryotic translation initiation factor eIF4G (a critical component of the protein synthesis machinery) and Nup98 (an
SUBMITTER: Serganov AA
PROVIDER: S-EPMC9168619 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
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