Members of the Chromobox Family Have Prognostic Value in Hepatocellular Carcinoma.

ABSTRACT: Liver cancer is the fifth most prevalent malignant tumor, while hepatocellular carcinoma represents the most prevalent subtype worldwide. Previous studies have associated the chromobox family, critical components of epigenetic regulatory complexes, with development of many malignancies owing to their role in inhibiting differentiation and promoting proliferation of cancer cells. However, little is known regarding their function in development and progression of hepatocellular carcinoma. In the present study, we analyzed differential expression, prognostic value, immune cell infiltration, and gene pathway enrichment of chromobox family in hepatocellular carcinoma patients. Next, we performed Pearson's correlation analysis to determine the relationships between chromobox family proteins with

SUBMITTER: Pan C 

PROVIDER: S-EPMC9168656 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature