Mining the Prognostic Role of DNA Methylation Heterogeneity in Lung Adenocarcinoma.

ABSTRACT:

Purpose

DNA methylation heterogeneity is a type of tumor heterogeneity in the tumor microenvironment, but studies on the identification of the molecular heterogeneity of the lung adenocarcinoma genome with respect to DNA methylation sites and their roles in lung cancer progression and prognosis are scarce.

Methods

Prognosis-associated DNA methylation subtypes were filtered by the Cox proportional hazards model and then established by unsupervised cluster analysis. Association analysis of these subtypes with clinical features and functional analysis of annotated genes potentially affected by methylation sites were performed. The robustness of the model was further tested by a Bayesian network classifier.

Results

Over 7 thousand methylation sites were associated with lu

SUBMITTER: Liao H 

PROVIDER: S-EPMC9168807 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature