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The neural substrate of spatial memory stabilization depends on the distribution of the training sessions.

ABSTRACT: SignificanceDistributed training has long been known to lead to more robust memory formation as compared to massed training. Using the water maze, a well-established task for assessing memory in laboratory rodents, we found that distributed and massed training differentially engage the dorsolateral and dorsomedial striatum, and optogenetic priming of dorsolateral striatum can artificially increase the robustness of massed training to the level of distributed training. Overall, our findings demonstrate that spatial memory consolidation engages different neural substrates depending on the training regimen, identifying a therapeutic avenue for memory enhancement.

SUBMITTER: Mastrorilli V

PROVIDER: S-EPMC9168842 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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The neural substrate of spatial memory stabilization depends on the distribution of the training sessions.

Mastrorilli Valentina V Centofante Eleonora E Antonelli Federica F Rinaldi Arianna A Mele Andrea A

Proceedings of the National Academy of Sciences of the United States of America 20220329 14

SignificanceDistributed training has long been known to lead to more robust memory formation as compared to massed training. Using the water maze, a well-established task for assessing memory in laboratory rodents, we found that distributed and massed training differentially engage the dorsolateral and dorsomedial striatum, and optogenetic priming of dorsolateral striatum can artificially increase the robustness of massed training to the level of distributed training. Overall, our findings demon ...[more]

PMID: 35349340

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