Two-day versus seven-day course of levofloxacin in acute COPD exacerbation: a randomized controlled trial.

ABSTRACT:

Introduction

Duration of antibiotic treatment in acute exacerbation of COPD (AECOPD) is most commonly based on expert opinion. Typical administration periods range from 5 to 7 days. A 2-day course with levofloxacin was not previously assessed. We performed a randomized clinical trial to evaluate the efficacy of 2-day versus 7-day treatment with levofloxacin in patients with AECOPD.

Methods and analysis

Patients with AECOPD were randomized to receive levofloxacin for 2 days and 5 days placebo (n = 155) or levofloxacin for 7 days (n = 155). All patients received a common dose of intravenous prednisone daily for 5 days. The primary outcome measure was cure rate, and secondary outcomes included need for additional antibiotics, ICU admission rate, re-exacerba

SUBMITTER: Messous S 

PROVIDER: S-EPMC9168850 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature