A Preliminary Study on Change of Serum Immunoglobulin G Glycosylation in Patients With Migraine.

ABSTRACT:

Background and objective

Migraine is a common neurological disease, but its pathogenesis is still unclear. Previous studies suggested that migraine was related to immunoglobulin G (IgG). We intended to analyze the immune characteristics of migraine from the perspective of IgG glycosylation and provide theoretical assistance for exploring its pathogenesis.

Methods

The differences in the serum level of IgG glycosylation and glycopeptides between patients with episodic migraine and healthy controls were analyzed by applying the poly(glycerol methacrylate)@chitosan (PGMA@CS) nanomaterial in combination with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). We constructed a binary classification model with a feedforward neural network us

SUBMITTER: Xu J 

PROVIDER: S-EPMC9168990 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature