A mechanoresponsive nano-sized carrier achieves intracellular release of drug on external ultrasound stimulus.

ABSTRACT: Control over intracellular release of therapeutic compounds incorporated into nano-carriers will open new possibilities for targeted treatments of various diseases including cancer, and viral and bacterial infections. Here we report our study on mechanoresponsive nano-sized liposomes which, following internalization by cells, achieve intracellular delivery of encapsulated cargo on application of external ultrasound stimulus. This is demonstrated in a bespoke cell reporter system designed to assess free drug in cytoplasm. Biophysical analyses show that drug release is attributable to the action of a mechanoresponsive spiropyran-based compound embedded in the liposomal lipid membrane. Exposure to external ultrasound stimulus results in opening of the molecular structure of the embedded spiro

SUBMITTER: Catania R 

PROVIDER: S-EPMC9169073 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature