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Autoregulation of switching behavior by cellular compartment size.

ABSTRACT: SignificanceBiochemical reactions often occur in small volumes within a cell, restricting the number of molecules to the hundreds or even tens. At this scale, reactions are discrete and stochastic, making reliable signaling difficult. This paper shows that the transition between discrete, stochastic reactions and macroscopic reactions can be exploited to make a self-regulating switch. This constitutes a previously unidentified kind of reaction network that may be present in small structures, such as synapses.

SUBMITTER: Jozsa M

PROVIDER: S-EPMC9169097 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Autoregulation of switching behavior by cellular compartment size.

Jozsa Monika M Donchev Tihol Ivanov TI Sepulchre Rodolphe R O'Leary Timothy T

Proceedings of the National Academy of Sciences of the United States of America 20220329 14

SignificanceBiochemical reactions often occur in small volumes within a cell, restricting the number of molecules to the hundreds or even tens. At this scale, reactions are discrete and stochastic, making reliable signaling difficult. This paper shows that the transition between discrete, stochastic reactions and macroscopic reactions can be exploited to make a self-regulating switch. This constitutes a previously unidentified kind of reaction network that may be present in small structures, suc ...[more]

PMID: 35349334

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