Clinical Relevance of Estrogen Reactivity in the Breast Cancer Microenvironment.

ABSTRACT:

Purpose

Estrogen signals play an important role in the phenotype of estrogen receptor-positive breast cancer. However, comprehensive analyses of the effect of responsiveness to estrogen signals on the tumor microenvironment and survival in large cohorts of primary breast cancer patients have been lacking. We aimed to test the hypothesis that estrogen reactivity affects gene expression and immune cell infiltration profiles in the tumor microenvironment and survival.

Methods

A total of 3,098 breast cancer cases were analyzed: 1,904 from the Molecular Taxonomy of Breast Cancer (METABRIC) cohort, 1,082 from The Cancer Genome Atlas (TCGA) cohort, and 112 from the Hokkaido University Hospital cohort. We divided the group into estrogen reactivity-high and estrogen reactivity-low gr

SUBMITTER: Takeshita T 

PROVIDER: S-EPMC9169154 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature