TLR4 rs4986790 polymorphism confers risk to Helicobacter pylori infection in Zhejiang, China and its enlightenment to nursing care.

ABSTRACT:

Purpose

Previous literatures on the association between TLR4 gene rs4986790 polymorphism and Helicobacter pylori infection risk reported conflict results. We conducted a case-control study and meta-analysis to investigate whether TLR4 gene rs4986790 polymorphism confers risk to Helicobacter pylori infection.

Patients and methods

254 patients with Helicobacter pylori positive and 235 patients with Helicobacter pylori negative were enrolled. PubMed, Embase, CNKI (Chinese national knowledge internet) were carefully searched and reviewed. Odds ratio (OR) together with 95% confidence interval (CI) were applied to calculate the association power.

Results

GG genotype of TLR4 gene rs4986790 polymorphism contributes increased risk to the population of Zhejiang, China (p = 0.01

SUBMITTER: He W 

PROVIDER: S-EPMC9169190 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature