A role for translational regulation by S6 kinase and a downstream target in inflammatory pain.

ABSTRACT:

Background and purpose

Translational controls pervade neurobiology. Nociceptors play an integral role in the detection and propagation of pain signals. Nociceptors can undergo persistent changes in their intrinsic excitability. Pharmacological disruption of nascent protein synthesis diminishes acute and chronic forms of pain-associated behaviours. However, the targets of translational controls that facilitate plasticity in nociceptors are unclear.

Experimental approach

We used ribosome profiling to probe the translational landscape in dorsal root ganglion (DRG) neurons from male Swiss-Webster mice, after treatment with nerve growth factor and IL-6. Expression dynamics of c-Fos were followed with immunoblotting and immunohistochemistry. The involvement of ribosomal protein S6

SUBMITTER: de la Pena JB 

PROVIDER: S-EPMC9169231 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature