Detection of increased pyruvate dehydrogenase flux in the human heart during adenosine stress test using hyperpolarized [1-¹³C]pyruvate cardiovascular magnetic resonance imaging.

ABSTRACT:

Background

Hyperpolarized (HP) [1-¹³C]pyruvate cardiovascular magnetic resonance (CMR) imaging can visualize the uptake and intracellular conversion of [1-¹³C]pyruvate to either [1-¹³C]lactate or ¹³C-bicarbonate depending on the prevailing metabolic state. The aim of the present study was to combine an adenosine stress test with HP [1-¹³C]pyruvate CMR to detect cardiac metabolism in the healthy human heart at rest and during moderate stress.

Methods

A prospective descriptive study was performed between October 2019 and August 2020. Healthy human subjects underwent cine CMR and HP [1-¹³C]pyruvate CMR at rest and during adenosine stress. HP [1-¹³C]pyruvate CMR images were acquired at the mid-left-vent

SUBMITTER: Joergensen SH 

PROVIDER: S-EPMC9169396 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature