First report on genome wide association study in western Indian population reveals host genetic factors for COVID-19 severity and outcome.

ABSTRACT: Different human races across the globe responded in a different way to the SARS-CoV-2 infection leading to different disease severity. Therefore, it is anticipated that host genetic factors have a straight association with the COVID-19. We identified a total 6, 7, and 6 genomic loci for deceased-recovered, asymptomatic-recovered, and deceased-asymptomatic group comparison, respectively. Unfavourable alleles of the markers nearby the genes which are associated with lung and heart diseases such as Tumor necrosis factor superfamily (TNFSF4&18), showed noteworthy association with the disease severity and outcome for the COVID-19 patients in the western Indian population. The markers found with significant association with disease prognosis or recovery are of value in determining the individual

SUBMITTER: Pandit R 

PROVIDER: S-EPMC9169419 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature