A role for endoplasmic reticulum dynamics in the cellular distribution of microtubules.

ABSTRACT: The dynamic distribution of the microtubule (MT) cytoskeleton is crucial for the shape, motility, and internal organization of eukaryotic cells. However, the basic principles that control the subcellular position of MTs in mammalian interphase cells remain largely unknown. Here we show by a combination of microscopy and computational modeling that the dynamics of the endoplasmic reticulum (ER) plays an important role in distributing MTs in the cell. Specifically, our physics-based model of the ER–MT system reveals that spatial inhomogeneity in the density of ER tubule junctions results in an overall contractile force that acts on MTs and influences their distribution. At steady state, cells rapidly compensate for local variability of ER junction density by dynamic formation, release, and m

SUBMITTER: Tikhomirova MS 

PROVIDER: S-EPMC9169640 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature