Enhanced endoscopic detection of occult gastric cancer in carriers of pathogenic CDH1 variants.

ABSTRACT:

Background

Germline inactivating variants in the CDH1 tumor suppressor gene impart an elevated lifetime risk of diffuse gastric cancer. The current endoscopic surveillance method depends upon random gastric biopsies for early cancer detection.

Methods

Asymptomatic adults with pathogenic or likely pathogenic CDH1 variants referred for endoscopic gastric cancer surveillance were included in this retrospective cohort. Upper gastrointestinal endoscopy was performed according to the consensus Cambridge method, in the early period, or a systematic (Bethesda) protocol as part of an ongoing natural history study. The primary outcome measure was cancer detection.

Results

Collectively, 135 endoscopic surveillance procedures were performed in 120 patients. Twenty-six (19%, 26/13

SUBMITTER: Curtin BF 

PROVIDER: S-EPMC9169699 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature