SLC38A10 Knockout Mice Display a Decreased Body Weight and an Increased Risk-Taking Behavior in the Open Field Test.

ABSTRACT: The solute carrier 38 family (SLC38) is a family of 11 members. The most common substrate among these are alanine and glutamine, and members are present in a wide range of tissues with important functions for several biological processes, such as liver and brain function. Some of these transporters are better characterized than others and, in this paper, a behavioral characterization of SLC38A10^-/- mice was carried out. A battery of tests for general activity, emotionality, motor function, and spatial memory was used. Among these tests, the elevated plus maze, Y-maze, marble burying and challenging beam walk have not been tested on the SLC38A10^-/- mice previously, while the open field and the rotarod tests have been performed by the International Mouse Phenotyping Con

SUBMITTER: Lindberg FA 

PROVIDER: S-EPMC9169716 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature