Ontology highlight
ABSTRACT:
SUBMITTER: Kremer KN
PROVIDER: S-EPMC9169816 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Kremer Kimberly N KN Buser Alan A Thumkeo Dean D Narumiya Shuh S Jacobelli Jordan J Pelanda Roberta R Torres Raul M RM
Proceedings of the National Academy of Sciences of the United States of America 20220408 15
Cancer and chronic infections often increase levels of the bioactive lipid, lysophosphatidic acid (LPA), that we have demonstrated acts as an inhibitory ligand upon binding LPAR5 on CD8 T cells, suppressing cytotoxic activity and tumor control. This study, using human and mouse primary T lymphocytes, reveals how LPA disrupts antigen-specific CD8 T cell:target cell immune synapse (IS) formation and T cell function via competing for cytoskeletal regulation. Specifically, we find upon antigen-speci ...[more]