Metabolomic signatures of low- and high-adiposity neonates differ based on maternal BMI.

ABSTRACT: Maternal obesity [body mass index (BMI) > 30 kg/m²] is associated with greater neonatal adiposity, cord blood (CB) insulin levels, and a proinflammatory phenotype at birth, contributing to risk of future cardiometabolic disease in the offspring. Variation in neonatal adiposity within maternal BMI groups is underappreciated, and it remains unclear whether the metabolic impairments at birth are an outcome of maternal obesity or excess fetal fat accrual. We examined the hypothesis that CB metabolites associated with fetal fat accrual differ between offspring of normal-weight and obese women. Umbilical venous blood was collected at the time of scheduled cesarean delivery from 50 normal-weight women (LE; pregravid BMI = 22.3 ± 1.7 kg/m²) and 50 obese women (OB; BMI = 34.5 

SUBMITTER: Aydogan Mathyk B 

PROVIDER: S-EPMC9169820 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature