Nucleosides Associated With Incident Ischemic Stroke in the REGARDS and JHS Cohorts.

ABSTRACT:

Background and objectives

Both genetic and environmental factors contribute to stroke risk. We sought to identify novel metabolites associated with incident stroke in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort and determine whether they reflected genetic or environmental variation.

Methods

This was a stroke case-cohort observational study nested in REGARDS. Cases were defined as incident stroke and metabolomic profiles were compared to a randomly selected control cohort. In baseline plasma samples, 162 metabolites were measured using liquid chromatography-tandem mass spectrometry. Cox proportional hazards models were adjusted for age, sex, race, and age by race in the base model. Fully adjusted models included traditional stroke risk factors

SUBMITTER: Ament Z 

PROVIDER: S-EPMC9169945 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature