Ontology highlight
ABSTRACT:
SUBMITTER: Neumeier D
PROVIDER: S-EPMC9170022 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Neumeier Daniel D Yermanos Alexander A Agrafiotis Andreas A Csepregi Lucia L Chowdhury Tasnia T Ehling Roy A RA Kuhn Raphael R Cotet Tudor-Stefan TS Brisset-Di Roberto Raphaël R Di Tacchio Mariangela M Antonialli Renan R Starkie Dale D Lightwood Daniel J DJ Oxenius Annette A Reddy Sai T ST
Proceedings of the National Academy of Sciences of the United States of America 20220429 18
The capacity of humoral B cell-mediated immunity to effectively respond to and protect against pathogenic infections is largely driven by the presence of a diverse repertoire of polyclonal antibodies in the serum, which are produced by plasma cells (PCs). Recent studies have started to reveal the balance between deterministic mechanisms and stochasticity of antibody repertoires on a genotypic level (i.e., clonal diversity, somatic hypermutation, and germline gene usage). However, it remains uncl ...[more]