A gut-derived metabolite alters brain activity and anxiety behaviour in mice.

ABSTRACT: Integration of sensory and molecular inputs from the environment shapes animal behaviour. A major site of exposure to environmental molecules is the gastrointestinal tract, in which dietary components are chemically transformed by the microbiota¹ and gut-derived metabolites are disseminated to all organs, including the brain². In mice, the gut microbiota impacts behaviour³, modulates neurotransmitter production in the gut and brain^4,5, and influences brain development and myelination patterns^6,7. The mechanisms that mediate the gut-brain interactions remain poorly defined, although they broadly involve humoral or neuronal connections. We previously reported that the levels of the microbial metabolite 4-ethylphenyl sulfate (4EPS) were i

SUBMITTER: Needham BD 

PROVIDER: S-EPMC9170029 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature