Allele-specific collateral and fitness effects determine the dynamics of fluoroquinolone resistance evolution.

ABSTRACT: Collateral sensitivity (CS), which arises when resistance to one antibiotic increases sensitivity toward other antibiotics, offers treatment opportunities to constrain or reverse the evolution of antibiotic resistance. The applicability of CS-informed treatments remains uncertain, in part because we lack an understanding of the generality of CS effects for different resistance mutations, singly or in combination. Here, we address this issue in the gram-positive pathogen Streptococcus pneumoniae by measuring collateral and fitness effects of clinically relevant gyrA and parC alleles and their combinations that confer resistance to fluoroquinolones. We integrated these results in a mathematical model that allowed us to evaluate how different in silico combination treatments impact the dynami

SUBMITTER: Liakopoulos A 

PROVIDER: S-EPMC9170170 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature