Time-dependent contraction of the SARS-CoV-2-specific T-cell responses in convalescent individuals.

ABSTRACT:

Background

Adaptive immunity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is decisive for disease control. Delayed activation of T cells is associated with a worse outcome in coronavirus disease 2019 (COVID-19). Although convalescent individuals exhibit solid T-cell immunity, to date, long-term immunity to SARS-CoV-2 is still under investigation.

Objectives

We aimed to characterize the specific T-cell response on the basis of the in vitro recall of IFN-γ-producing cells to in silico-predicted peptides in samples from SARS-CoV-2 convalescent individuals.

Methods

The sequence of the SARS-CoV-2 genome was screened, leading to the identification of specific and promiscuous peptides predicted to be recognized by CD4⁺ an

SUBMITTER: Fernandes ER 

PROVIDER: S-EPMC9170273 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature