Sugar-sweetened beverage and sugar consumption and colorectal cancer incidence and mortality according to anatomic subsite.

ABSTRACT:

Background

Recent preclinical research strongly suggests that dietary sugars can enhance colorectal tumorigenesis by direct action, particularly in the proximal colon that unabsorbed fructose reaches.

Objectives

We aimed to examine long-term consumption of sugar-sweetened beverages (SSBs) and total fructose in relation to incidence and mortality of colorectal cancer (CRC) by anatomic subsite.

Methods

We followed 121,111 participants from 2 prospective US cohort studies, the Nurses' Health Study (1984-2014) and Health Professionals Follow-Up Study (1986-2014), for incident CRC and related death. Cox proportional hazards regression was used to compute HRs and 95% CIs.

Results

During follow-up, we documented 2733 incident cases of CRC with a known anatomic locatio

SUBMITTER: Yuan C 

PROVIDER: S-EPMC9170474 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature