Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients.

ABSTRACT: While studies have elucidated many pathophysiological elements of COVID-19, little is known about immunological changes during COVID-19 resolution. We analyzed immune cells and phosphorylated signaling states at single-cell resolution from longitudinal blood samples of patients hospitalized with COVID-19, pneumonia and/or sepsis, and healthy individuals by mass cytometry. COVID-19 patients showed distinct immune compositions and an early, coordinated, and elevated immune cell signaling profile associated with early hospital discharge. Intra-patient longitudinal analysis revealed changes in myeloid and T cell frequencies and a reduction in immune cell signaling across cell types that accompanied disease resolution and discharge. These changes, together with increases in regulatory T cells a

SUBMITTER: Burnett CE 

PROVIDER: S-EPMC9170540 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature