Potential prognosis index for m⁶A-related mRNA in cholangiocarcinoma.

ABSTRACT:

Background

Cholangiocarcinoma (CHOL) is a malignant tumor that originates in the extrahepatic bile duct and can extend from the hilar region to the lower end of the common bile duct. The prognosis of CHOL patients is particularly poor; therefore, in this study, we screened mRNAs correlated with N6-methyladenosine (m⁶A) to construct a risk model for prognosis in CHOL.

Methods

The TCGA-CHOL dataset was applied to obtain and analyze the coexpression of 1281 m⁶A-related mRNAs, from which 14 were selected for further analysis through univariate proportional hazards (cox) regression analysis. Aryl hydrocarbon receptor interacting protein (AIP), CCAAT/enhancer binding protein beta (CEBPB), syndecan1 (SDC1), vacuolar protein sorting 25 homolog (VPS25) and synta

SUBMITTER: Zhu H 

PROVIDER: S-EPMC9170563 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature