Downregulation of nc886 contributes to prostate cancer cell invasion and TGFβ1-induced EMT.

ABSTRACT: Epithelial-to-mesenchymal transition (EMT) activation is important in cancer progression and metastasis. Evidence indicates that nc886 is a representative Pol III gene that processes microRNA products via Dicer and further downregulates its target gene transforming growth factor- β1 (TGF-β1), which is the most prominent inducer of EMT in prostate cancer (PC). Consistent with the previous literature, we found that nc886 downregulation was strongly associated with metastatic behavior and showed worse outcomes in PC patients. However, little is known about the association between nc886 and the EMT signaling pathway. We developed a PC cell model with stable overexpression of nc886 and found that nc886 changed cellular morphology and drove MET. The underlying

SUBMITTER: Yang R 

PROVIDER: S-EPMC9170576 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature