Mutational landscape of gastric adenocarcinoma in Latin America: A genetic approach for precision medicine.

ABSTRACT: Latin-America (LATAM) is the second region in gastric cancer incidence; gastric adenocarcinoma (GA) represents 95% of all cases. We provide a mutational landscape of GA highlighting a) germline pathogenic variants associated with hereditary GA, b) germline risk variants associated with sporadic GA, and c) somatic variants present in sporadic GA in LATAM, and analyze how this landscape can be applied for precision medicine. We found that Brazil, Chile, Colombia, Mexico, Peru, and Venezuela are the countries with more published studies from LATAM explicitly related to GA. Our analysis displayed that different germline pathogenic variants for the CDH1 gene have been identified for hereditary GA in Brazilian, Chilean, Colombian, and Mexican populations. An increased risk of developing s

SUBMITTER: Cerrato-Izaguirre D 

PROVIDER: S-EPMC9170608 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature