Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder.

ABSTRACT: The nucleus accumbens (NAc) is considered a hub of reward processing and a growing body of evidence has suggested its crucial role in the pathophysiology of major depressive disorder (MDD). However, inconsistent results have been reported by studies on reward network-focused resting-state functional MRI (rs-fMRI). In this study, we examined functional alterations of the NAc-based reward circuits in patients with MDD via meta- and mega-analysis. First, we performed a coordinated-based meta-analysis with a new SDM-PSI method for all up-to-date rs-fMRI studies that focused on the reward circuits of patients with MDD. Then, we tested the meta-analysis results in the REST-meta-MDD database which provided anonymous rs-fMRI data from 186 recurrent MDDs and 465 healthy controls. Decreased function

SUBMITTER: Ding YD 

PROVIDER: S-EPMC9170720 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature