SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells.

ABSTRACT:

Objective

Mitochondrial "retrograde" signaling may stimulate organelle biogenesis as a compensatory adaptation to aberrant activity of the oxidative phosphorylation (OXPHOS) system. To maintain energy-consuming processes in OXPHOS deficient cells, alternative metabolic pathways are functionally coupled to the degradation, recycling and redistribution of biomolecules across distinct intracellular compartments. While transcriptional regulation of mitochondrial network expansion has been the focus of many studies, the molecular mechanisms promoting mitochondrial maintenance in energy-deprived cells remain poorly investigated.

Methods

We performed transcriptomics, quantitative proteomics and lifespan assays to identify pathways that are mechanistically linked to mitochondrial ne

SUBMITTER: Jackson J 

PROVIDER: S-EPMC9170783 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature