Single-nucleus transcriptome analysis reveals disease- and regeneration-associated endothelial cells in white matter vascular dementia.

ABSTRACT:

Background

Vascular dementia (VaD) is the accumulation of vascular lesions in the subcortical white matter of the brain. These lesions progress and there is no direct medical therapy.

Aims

To determine the specific cellular responses in VaD so as to provide molecular targets for therapeutic development.

Materials and methods

Single-nucleus transcriptome analysis was performed in human periventricular white matter (PVWM) samples of VaD and normal control (NC) subjects.

Results

Differential analysis shows that cell type-specific transcriptomic changes in VaD are associated with the disruption of specific biological processes, including angiogenesis, immune activation, axonal injury and myelination. Each cell type in the neurovascular unit within white matter has

SUBMITTER: Mitroi DN 

PROVIDER: S-EPMC9170821 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature