Aptamer-armed nanostructures improve the chemotherapy outcome of triple-negative breast cancer.

ABSTRACT: Triple-negative breast cancer is an aggressive subtype of breast cancer that is primarily treated using systemic chemotherapy due to the lack of a specific cell surface marker for drug delivery. Cancer cell-specific aptamer-mediated drug delivery is a promising targeted chemotherapy for marker-unknown cancers. Using a poorly differentiated carcinoma cell-specific DNA aptamer (PDGC21T), we formed a self-assembling circinate DNA nanoparticle (Apt^21TNP) that binds triple-negative breast cancer cells. Using our previously designed pH-sensitive dendrimer-conjugated doxorubicin (DDOX) as the payload, we found that each nanoparticle loaded 30 doxorubicin molecules to form an Apt^21TNP-DDOX nanomedicine that is stable in human plasma. Upon cell binding, Apt^21TNP-DDO

SUBMITTER: Wan Q 

PROVIDER: S-EPMC9171151 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature