Impact of Extensively Hydrolyzed Infant Formula on Circulating Lipids During Early Life.

ABSTRACT:

Background

Current evidence suggests that the composition of infant formula (IF) affects the gut microbiome, intestinal function, and immune responses during infancy. However, the impact of IF on circulating lipid profiles in infants is still poorly understood. The objectives of this study were to (1) investigate how extensively hydrolyzed IF impacts serum lipidome compared to conventional formula and (2) to associate changes in circulatory lipids with gastrointestinal biomarkers including intestinal permeability.

Methods

In a randomized, double-blind controlled nutritional intervention study (n = 73), we applied mass spectrometry-based lipidomics to analyze serum lipids in infants who were fed extensively hydrolyzed formula (HF) or conventional, regular formula (RF).

SUBMITTER: Lamichhane S 

PROVIDER: S-EPMC9171511 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature